S&P 500 Healthcare Sector SEC Filings — July 23, 2026

USA S&P 500 Healthcare

By Gunpowder Editorial ·

3 high priority 3 medium priority 6 total filings analysed

Executive Summary

The S&P 500 Healthcare sector delivered a robust Q2 2026, with all reporting companies showing top-line growth, led by Edwards Lifesciences (+13.6% YoY) and Thermo Fisher (+10% YoY), while J&J posted a more moderate 6.6% increase. Margin performance was a key differentiator: Thermo Fisher and J&J expanded operating margins, whereas Edwards saw flat gross margins due to FX headwinds.

The most critical development is Edwards' raised full-year guidance, signaling sustained momentum in structural heart devices. Insider activity was limited to routine equity awards at Vertex, providing no directional signal. Capital allocation is mixed, with Thermo Fisher pursuing a divestiture (microbiology business) while J&J maintains a strong balance sheet. The portfolio

Materiality, sentiment, and priority are scored by Gunpowder’s analysis pipeline. How we score filings →

Filing types in this digest: 8-K · Schedule 13G · Form 4 · 10-Q

Tracking the trend? Catch up on the prior S&P 500 Healthcare Sector SEC Filings digest from July 22, 2026.

Filing Analyses (6)
THERMO FISHER SCIENTIFIC INC. 8-K positive materiality 8/10

23-07-2026

Thermo Fisher Scientific reported strong Q2 2026 results with revenue growing 10% to $11.99B, driven by 5% organic growth. GAAP diluted EPS grew 9% to $4.68 and adjusted EPS grew 13% to $6.03. However, net income margin attributable to the company slightly declined to 14.5% from 14.9% in the prior year quarter, and the company announced the divestiture of its microbiology business.

  • · Revenue growth included 5% from acquisitions and 1% from currency translation, with organic growth at 5%.
  • · GAAP operating margin improved to 17.4% from 16.9% in Q2 2025.
  • · Adjusted operating margin improved to 22.8% from 21.9% in Q2 2025.
  • · Free cash flow increased 52% YoY to $1.68B.
  • · Company repurchased $1.0B of stock during the quarter.
  • · Company announced divestiture of its microbiology business.
  • · All four business segments reported revenue growth: Life Sciences Solutions +12.6%, Analytical Instruments +6.9%, Specialty Diagnostics +6.3%, Laboratory Products and Biopharma Services +11.6%.
  • · Segment income margins improved across all segments: Life Sciences Solutions 37.0% (vs 36.8%), Analytical Instruments 23.0% (vs 18.8%), Specialty Diagnostics 27.7% (vs 27.0%), Laboratory Products and Biopharma Services 14.0% (vs 13.8%).
  • · Net income margin attributable to Thermo Fisher declined to 14.5% from 14.9% in Q2 2025.
  • · Weighted average diluted shares decreased to 371M from 378M, reflecting share repurchases.
ELI LILLY & Co SC 13G/A neutral materiality 3/10

23-07-2026

Lilly Endowment, Inc. filed an amended Schedule 13G disclosing beneficial ownership of 90,376,978 shares of Eli Lilly & Co common stock as of June 30, 2026, representing 9.6% of the 941,741,406 shares outstanding. The filing reflects a routine ownership update with no change in the nature of the holding (all shares are directly owned, none acquired via options).

  • · The filing is an amendment (Schedule 13G/A) filed under Rule 13d-1(d).
  • · Lilly Endowment, Inc. is a Section 501(c)(3) private foundation organized under Indiana law.
  • · No shares are deemed beneficially owned via a right to acquire; all 90,376,978 shares are directly held.
  • · The filing date is July 23, 2026, with an as-of date of June 30, 2026.
VERTEX PHARMACEUTICALS INC / MA 4 neutral materiality 5/10

23-07-2026

EVP, Chief Reg. & Quality Off. Tatsis Ourania was awarded 8,251 Common Stock. Tatsis Ourania holds 53,572 shares after the transaction.

  • · EVP, Chief Reg. & Quality Off. Tatsis Ourania was awarded 8,251 Common Stock
JOHNSON & JOHNSON 10-Q mixed materiality 8/10

23-07-2026

Johnson & Johnson reported Q2 2026 sales of $25.3B, up 6.6% YoY from $23.7B, with gross margin improving to 68.2% from 67.9%. However, net earnings for the quarter were essentially flat at $5.534B vs $5.537B, and diluted EPS declined to $2.27 from $2.29. For the six-month period, net earnings dropped 34.9% to $10.769B from $16.536B, largely due to a prior-year gain in Other income/expense. The company maintained a strong balance sheet with total assets of $201.1B and shareholders' equity of $85.0B.

  • · Q2 2026 gross profit was $17.259B (68.2% of sales) vs $16.115B (67.9%) in Q2 2025.
  • · Selling, marketing and administrative expenses rose to $6.432B (25.4% of sales) from $5.889B (24.8%).
  • · Research and development expense increased to $3.653B (14.4% of sales) from $3.516B (14.8%).
  • · Interest income decreased to $219M from $260M; interest expense net was $281M vs $308M.
  • · Other (income) expense net was $331M expense in Q2 2026 vs $107M expense in Q2 2025.
  • · Restructuring charges were $34M in Q2 2026 vs $64M in Q2 2025.
  • · Provision for taxes on income was $1.213B (4.8% of sales) vs $954M (4.0%).
  • · Cash dividends paid were $1.34 per share in Q2 2026, totaling $3.227B.
  • · Share repurchases (including excise tax) were $219M in Q2 2026.
  • · Total current assets increased to $59.774B from $55.624B at year-end 2025.
  • · Total current liabilities were $54.895B vs $54.126B at year-end 2025.
  • · Long-term debt decreased to $37.344B from $39.438B.
  • · Accumulated other comprehensive loss improved to $(13.951)B from $(14.930)B.
  • · In-process R&D impairments of $36M were recorded in H1 2026 vs nil in H1 2025.
  • · Other (income) expense net for H1 2026 was $625M expense vs $(7.214)B income in H1 2025 (prior year included a large gain).
Edwards Lifesciences Corp 8-K positive materiality 9/10

23-07-2026

Edwards Lifesciences reported Q2 2026 sales of $1.74 billion, up 13.6% YoY (12.5% constant currency), driven by strong TAVR growth of 11.3% to $1.26 billion and TMTT growth of 47.3% to $195.9 million. Adjusted EPS was $0.78, beating expectations, and the company raised its full-year constant currency sales growth guidance to 10%-11% from 9%-11%. However, gross profit margin remained flat at 77.5% due to FX headwinds, and the company now expects its effective tax rate to be at the high end of its 16%-19% range, partially offsetting the positive momentum.

  • · Q2 adjusted EPS was $0.78, benefiting from better-than-expected topline and planned phasing of strategic investments.
  • · Q2 GAAP EPS was $0.42.
  • · Full-year adjusted EPS guidance reaffirmed at $2.95-$3.05 (17% growth at midpoint) despite higher expected tax rate.
  • · Q3 2026 guidance: total sales $1.63-$1.71 billion, adjusted EPS $0.71-$0.77.
  • · Cash and equivalents $2.9B, total debt $600M, $1.5B remaining under share repurchase authorization.
  • · Gross margin expected at lower end of 78%-79% full-year guidance due to FX hedging impacts.
  • · Operating margin expected at high end of 28%-29% guidance, ~150 bps constant currency expansion for full year.
  • · Effective tax rate now expected at high end of 16%-19% range due to Pillar Two legislation delay and California R&D credit restrictions.
  • · CMS final decision memo on TAVR NCD expected in September 2026.
  • · Q4 2026 expected approvals: PASCAL tricuspid indication in U.S., next-gen PASCAL with Capture Clarity in U.S. and Europe, and CLASP IITR trial results at TCT.
  • · Surgical segment grew 6.5% YoY, slower than TAVR and TMTT.
  • · R&D spending decreased as a percentage of sales to 16.0% from 18.0% YoY, reflecting revenue growth and strategic prioritization.
VERTEX PHARMACEUTICALS INC / MA 4 neutral materiality 4/10

23-07-2026

EVP Chief Patient & Ext Af Off Sachdev Amit was awarded 8,251 Common Stock. Sachdev Amit holds 66,512 shares after the transaction.

  • · EVP Chief Patient & Ext Af Off Sachdev Amit was awarded 8,251 Common Stock

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